本刊推荐：研究人员针对急性早幼粒细胞白血病(APL)中罕见变异型融合基因开展研究，报道一例仅携带单PML::RARA融合（位于der(17)）而无典型RARA::PML reciprocal融合的APL病例。通过细胞遗传学与分子检测技术，证实该患者对全反式维甲酸(ATRA)联合三氧化二砷(ATO)疗法 ...

提到急性早幼粒细胞白血病（acute promyelocytic leukaemia withPML-RARA, APL withPML-RARA）大家都能立刻想到骨髓涂片上两种典型的细胞形态，一种是粗颗粒型，一种是细颗粒型。随着分子生物学检查手段的不断发展和应用，发现，原来还存在APL变异型和APL-like leukemia，后面 ...

APL is a distinct subtype of myeloid leukaemia that in almost 100% of cases is associated with chromosomal translocations involving the PML and retinoic acid receptor α (RARA) loci, leading to the ...

Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leukemia (APL ...

本研究针对急性早幼粒细胞白血病（APL）诊断中约1%的隐匿性病例（常规FISH检测阴性），通过采用48小时快速NGS技术成功检出PML-RARA融合基因，证实了该技术对APL早期诊断的关键作用。研究团队在典型DIC症状但FISH阴性病例中，利用Oncomine Myeloid Assay GX v2同时检出PML ...

Acute promyelocytic leukemia (APL) is driven by an oncogenic chromosomal translocation fusing the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes. APL responds to two ...